Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiosensitization and apoptosis

R J Muschel1, D E Soto, W G McKenna

  • 1Department of Pathology and Lab Medicine, University of Pennsylvania, Philadelphia 19104, USA.

Oncogene
|January 23, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Nature communications·2018
Same author

Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity.

European heart journal. Cardiovascular Imaging·2016
Same author

[Not Available].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2016
Same author

Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.

Oncogene·2016
Same author

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

Cell death & disease·2012
Same author

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

British journal of cancer·2012
Same journal

SRD5A3-mediated aberrant N-glycosylation of SCARA5 promotes ferroptosis in lung adenocarcinoma.

Oncogene·2026
Same journal

Aberrant splicing in human cancer shows possible functional impact on transcription factors.

Oncogene·2026
Same journal

The crosstalk between RNA m6A modification and protein lactylation: emerging insights into tumor progression.

Oncogene·2026
Same journal

Correction: Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway.

Oncogene·2026
Same journal

Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C-mutant non-small cell lung cancer.

Oncogene·2026
Same journal

Histone lactylation-driven IGF2BP3 promotes intrahepatic cholangiocarcinoma progression via SPP1/CD44-dependent macrophage polarization.

Oncogene·2026
See all related articles

Radiation therapy is a cornerstone of cancer treatment, but its effectiveness is limited by damage to healthy tissues. Targeting oncogenes could selectively sensitize tumor cells to radiation, improving treatment outcomes.

Area of Science:

  • Oncology
  • Radiation Biology
  • Molecular Biology

Background:

  • Radiation toxicity to tissues is well-established and forms the basis of radiotherapy.
  • Current radiotherapy is limited by the sensitivity of normal tissues, impacting treatment efficacy.
  • Selective sensitization of tumor cells while sparing normal tissues is a key goal for improving cancer therapy.

Purpose of the Study:

  • To explore the potential of targeting oncogenes to enhance tumor radiosensitivity.
  • To investigate methods for sensitizing tumor cells to radiation while sparing normal tissues.
  • To leverage oncogene alterations in tumors for improved cancer treatment outcomes.

Main Methods:

  • Identifying oncogenes frequently altered in tumors but not in normal tissues.

Related Experiment Videos

  • Investigating the role of oncogenes in modulating cellular response to radiation.
  • Developing strategies to target oncogenes for radiosensitization and apoptosis induction in tumors.

    • Main Results:

    • Oncogenes are frequently altered in tumors and absent in normal tissues.
    • These alterations present a potential target for differential radiosensitization.
    • Targeting oncogenes may offer a way to selectively increase tumor cell killing by radiation.

    Conclusions:

    • Oncogenes represent promising targets for enhancing radiotherapy efficacy.
    • Modulating oncogene activity could lead to tumor cell sensitization to radiation.
    • This approach holds potential for improving cancer treatment by sparing normal tissues.