Related Experiment Videos
Once-daily therapy for streptococcal pharyngitis with amoxicillin
H M Feder1, M A Gerber, M F Randolph
1Department of Family Medicine and Pediatrics, University of Connecticut School of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Pediatrics
|January 26, 1999
Summary
Once-daily amoxicillin is as effective as penicillin V for treating group A beta-hemolytic streptococcal (GABHS) pharyngitis. This convenient dosing regimen may improve patient compliance for GABHS infections.
Area of Science:
- Infectious Diseases
- Pediatrics
- Pharmacology
Background:
- Group A beta-hemolytic streptococcal (GABHS) pharyngitis is a common childhood infection.
- Current treatment regimens often involve multiple daily doses, potentially impacting patient compliance.
Purpose of the Study:
- To evaluate the effectiveness of a once-daily amoxicillin regimen compared to standard penicillin V for GABHS pharyngitis.
- To assess if simplified dosing improves treatment outcomes and compliance.
Main Methods:
- A randomized study comparing once-daily oral amoxicillin (750 mg) with three-times-daily oral penicillin V (250 mg) for 10 days in children with GABHS pharyngitis.
- Patient compliance was monitored via urine antimicrobial activity.
Main Results:
- No significant difference in clinical or bacteriologic response at 18-24 hours between the amoxicillin and penicillin V groups.
- Bacteriologic treatment failure rates were 5% for once-daily amoxicillin versus 11% for penicillin V.
Conclusions:
- Once-daily amoxicillin is a viable and effective alternative to multi-daily penicillin V for treating GABHS pharyngitis.
- This simplified regimen could enhance patient compliance and treatment adherence.