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Swimming Induced Paralysis to Assess Dopamine Signaling in Caenorhabditis elegans

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Parkinsonism after a wasp sting

N A Leopold¹, W Bara-Jimenez, M Hallett

¹Department of Medicine, Crozer-Chester Medical Center, Upland, Pennsylvania, USA.

Movement Disorders : Official Journal of the Movement Disorder Society

|January 26, 1999

Summary

A wasp sting triggered parkinsonism in a man, leading to severe basal ganglia damage. Immunoglobulin therapy and plasmapheresis halted and reversed his symptoms, suggesting Hymenoptera stings as a potential cause of extrapyramidal syndromes.

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Area of Science:

Neurology
Toxicology

Background:

Insect stings, particularly from the Hymenoptera order, can cause diverse neurological complications.
Parkinsonism is a neurological disorder characterized by tremors, rigidity, and bradykinesia.

Observation:

A 49-year-old man developed parkinsonism following a wasp sting.
His condition progressed to severe akinetic-rigid syndrome with basal ganglia destruction.
Standard antiparkinsonian medications were ineffective.

Findings:

The patient's symptoms stabilized and partially reversed with plasmapheresis, intravenous immunoglobulin, and azathioprine.
Magnetic resonance imaging revealed significant basal ganglia destruction.
Literature review indicates a need to consider Hymenoptera stings in extrapyramidal syndromes.

Implications:

Hymenoptera stings represent a potential, albeit rare, cause of acute and chronic extrapyramidal syndromes.
This case highlights the importance of considering insect stings in the differential diagnosis of parkinsonism.
Novel therapeutic strategies involving immunomodulation may be effective in managing neurotoxic injuries from insect stings.