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Related Experiment Videos

Maternal thyroid function in multiple pregnancy: the variable thyrotropic activity of human chorionic gonadotropin

N Sakaguchi1, M Yoshimura, M Nishikawa

  • 1Second Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan. sakaguch@takii.kmu.ac.jp

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|January 26, 1999
PubMed
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Multiple pregnancies show higher human chorionic gonadotropin (hCG) levels but normal thyroid hormone levels compared to singleton pregnancies. The thyrotropic action of hCG differs significantly in multiple pregnancies, indicating altered thyroid regulation.

Area of Science:

  • Endocrinology
  • Reproductive Medicine
  • Maternal-Fetal Medicine

Background:

  • Human chorionic gonadotropin (hCG) is known to influence thyroid function during pregnancy.
  • The impact of multiple pregnancies on hCG levels and subsequent thyroid regulation requires further investigation.

Purpose of the Study:

  • To evaluate thyroid function in multiple pregnancies.
  • To assess the thyrotropic action of hCG in women with multiple gestations.
  • To compare thyroid function and hCG characteristics between multiple and singleton pregnancies.

Main Methods:

  • Serum samples from 9 women with multiple pregnancies (twins and triplets) and 27 with singleton pregnancies were analyzed.
  • Measurements included serum hCG, free triiodothyronine (free T3), free thyroxine (free T4), and thyroid-stimulating activity (TSA) using FRTL-5 cells.

Related Experiment Videos

  • Bioactivity/immunoreactivity ratios of hCG were determined.

    • Main Results:

    • Serum hCG levels were significantly higher in multiple pregnancies during the second and third trimesters.
    • Free T3 and T4 concentrations did not differ between multiple and singleton pregnancies.
    • Thyroid-stimulating activity was higher in the first trimester of multiple pregnancies but showed no correlation with hCG levels, unlike in singleton pregnancies.

    Conclusions:

    • Despite elevated hCG, thyroid hormone levels remain normal in multiple pregnancies.
    • The thyrotropic action of hCG is altered in multiple pregnancies, potentially due to heterogeneous hCG molecular forms.
    • This suggests a complex interplay between hCG and thyroid regulation specific to multiple gestations.