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Testosterone and depression in aging men

S N Seidman1, B T Walsh

  • 1Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|January 27, 1999
PubMed
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Low testosterone levels in aging men are linked to depression. Some men with depression may improve with androgen treatment, suggesting a connection between testosterone and mood.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Psychiatry

Background:

  • Testosterone influences male neurobehavioral functions, including mood and cognition.
  • Testosterone secretion declines with age, affecting a significant percentage of older men.
  • The psychiatric consequences of age-related testosterone decline, particularly depression, are not fully understood.

Purpose of the Study:

  • To review the physiology of the aging hypothalamic-pituitary-gonadal axis in men.
  • To examine the evidence linking testosterone levels to major depression in men.

Main Methods:

  • Literature review of observational studies comparing testosterone levels in depressed and non-depressed men.
  • Analysis of treatment studies using exogenous androgens for male depression.

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Main Results:

  • Some depressed older men exhibit testosterone levels that are dependent on their state.
  • Androgen treatment shows potential for improving depressive symptoms in some men.

Conclusions:

  • Low testosterone may be associated with depression in some aging men.
  • Androgen therapy could be a viable treatment option for specific cases of male depression.