Class I peptides involved in the indirect pathway of allorecognition

1. Donor HLA class I peptides that best "fit" the recipient's HLA-class II antigen peptide motifs were determined as peptide scores. 2. Transplants with high-scoring donor peptide mismatches had reduced long-term outcome. 3. Peptides identified in this analysis may be useful for induction of tolerance, diagnosis of rejection, and improvement in allocation of more histocompatible kidneys.