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Updated: Aug 10, 2026
08:48
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
[Candida krusei (Castellani) Berkhout--a potential pathogen with growing importance]
1Ustav experimentální biofarmacie, Akademie vĕd Ceské republiky, Hradec Králové.
Summary
Candida krusei infections are rising due to fluconazole resistance, particularly in hospitals. This yeast
Area of Science:
- Medical Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Candida krusei is an opportunistic fungal pathogen.
- Increasing prevalence of Candida krusei infections observed globally.
- Candida krusei exhibits intrinsic resistance to fluconazole.
Purpose of the Study:
- To review the biological properties, ecology, and pathogenicity of Candida krusei.
- To analyze factors contributing to the propagation and clinical significance of Candida krusei.
- To discuss the impact of fluconazole resistance on Candida krusei infections.
Main Methods:
- Literature review and data synthesis.
- Comparative analysis of Candida krusei and Candida albicans.
- Antimycotic sensitivity profiling.
Main Results:
- Candida krusei causes various human diseases.
- Fluconazole resistance is a key factor in C. krusei proliferation.
- Hospitalized patients are a primary reservoir for fluconazole-resistant C. krusei.
Conclusions:
- Fluconazole resistance significantly drives the emergence of Candida krusei.
- Understanding C. krusei ecology and resistance is crucial for infection control.
- Further research is needed to clarify fluconazole's role in shaping the Candida species spectrum.
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