Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A general solution for nonparametric control of a linear system using computer-controlled infusion pumps

D Verotta1

  • 1School of Pharmacy, Department of Biopharmaceutical Sciences, University California at San Francisco 94143-0446, USA. davide@ariel.ucsf.edu

IEEE Transactions on Bio-Medical Engineering
|January 27, 1999
PubMed
Summary

This study presents a new algorithm for computer-controlled infusion pumps (CCIPs) that accurately controls drug delivery using any unit impulse response (UIR) function, improving patient safety and treatment efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.

Journal of perinatology : official journal of the California Perinatal Association·2013
Same author

Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.

Clinical pharmacology and therapeutics·2009
Same author

Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects.

British journal of clinical pharmacology·2005
Same author

Selecting reliable pharmacokinetic data for explanatory analyses of clinical trials in the presence of possible noncompliance.

Journal of pharmacokinetics and pharmacodynamics·2001
Same author

A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin.

Journal of pharmaceutical sciences·2001
Same author

Linear mixed-effect multivariate adaptive regression splines applied to nonlinear pharmacokinetics data.

Journal of biopharmaceutical statistics·2000

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Biomedical Engineering
  • Computational Biology

Background:

  • Current computer-controlled infusion pumps (CCIPs) often rely on multiexponential functions to model drug pharmacokinetics, which are frequently inaccurate approximations.
  • The complex, non-exponential profiles of drug concentrations, especially at early and later times post-administration, limit the precision of existing CCIP algorithms.

Purpose of the Study:

  • To develop a generalizable algorithm for CCIPs capable of handling arbitrary unit impulse response (UIR) functions.
  • To improve the accuracy and safety of intravenous drug administration by accommodating complex drug elimination profiles.

Main Methods:

  • Derived a general approach for CCIPs applicable to any UIR function.
  • Utilized a nonparametric representation of the UIR using spline functions for a specific implementation.

Related Experiment Videos

  • Incorporated computational simplicity and the ability to enforce constraints, such as preventing overshoot to avoid toxicity.

    • Main Results:

    • Demonstrated a flexible CCIP control strategy adaptable to diverse drug pharmacokinetic profiles.
    • Successfully controlled substance concentrations at a site distinct from the administration site.
    • Validated the approach using real-world data for lodocaine, veralipride, and thiopental.

    Conclusions:

    • The developed general approach offers a robust solution for CCIP drug dosing, overcoming limitations of multiexponential models.
    • This method enhances the precision of drug delivery and allows for safer administration by managing concentration profiles and avoiding toxicity.
    • The spline-based implementation provides a computationally efficient and adaptable tool for advanced pharmacokinetic control.