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[Tumor suppressor genes with special emphasis on the APC tumor suppressor gene]
1Zavod za biologiju, Medicinski fakultet Sveucilista u Zagrebu.
Abstract:
Tumor suppressor genes play a central role in the genesis and progression of human cancers. Genetic alterations of tumor suppressor genes have been found in a variety of hereditary and nonhereditary cancers. Persons that carry a hereditary mutation in tumor suppressor genes are strongly predisposed to one or more kinds of cancer. This review brings current developments in the field of tumor suppressor genes. Special emphasis is dedicated to recently discovered tumor suppressor gene APC (adenomatous polyposis coli) whose mutations are responsible for familial adenomatous polyposis (FAP). The known mutations of the APC gene are described. The role of the APC gene in tumor development, as well as the possibility for presymptomatic genetic testing is also discussed in the paper.
Insights
Tumor suppressor genes are crucial in cancer development. This review highlights the APC gene
Area of Science:
- Oncology and Genetics
- Molecular Biology
Context:
- Tumor suppressor genes are critical in preventing cancer formation.
- Genetic alterations in these genes are linked to hereditary and non-hereditary cancers.
- Individuals with inherited mutations face a higher risk of developing multiple cancers.
Purpose:
- To review current advancements in tumor suppressor gene research.
- To focus on the adenomatous polyposis coli (APC) gene and its mutations.
- To discuss the APC gene's role in tumorigenesis and genetic testing.
Summary:
- This review details the significance of tumor suppressor genes in human cancers.
- It specifically examines the adenomatous polyposis coli (APC) gene, mutations of which cause familial adenomatous polyposis (FAP).
- The paper covers known APC mutations, its function in tumor development, and presymptomatic genetic testing options.
Impact:
- Provides an updated overview of tumor suppressor gene research.
- Highlights the importance of the APC gene in FAP and general cancer development.
- Informs about genetic testing possibilities for individuals at risk.