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Updated: Aug 14, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Fluorimetric and solubility studies of nadolol and atenolol in SDS micelles
B de Castro1, P Gameiro, C Guimarães
1CEQUP/Departamento de Química, Faculdade de Ciéncias, Universidade do Porto, Portugal.
Abstract:
The effect of sodium dodecyl sulfate (SDS) micelles on the spectrofluorimetric intensities and on the solubility of two beta-blockers (atenolol and nadolol) were studied at 25.0 +/- 0.1 degrees C and I = 0.1 M NaCl. From the dependence of these physical properties on SDS concentration it was possible to calculate the binding constants drug-micelle, and it was found that both techniques yield similar results for the binding constants, and that are in agreement with those calculated from the effect of micelles on the apparent acidity constants of the beta-blockers.
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