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Expression of platelet-derived endothelial cell growth factor (PD-ECGF) related to angiogenesis in ovarian
J Fujimoto1, H Sakaguchi, R Hirose
1Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan.
The Journal of Clinical Endocrinology and Metabolism
|January 27, 1999
Abstract:
Platelet-derived endothelial cell growth factor (PD-ECGF) is expressed in the lining epithelial cells of ovarian endometriomas, and in interstitial cells of the subepithelial area with angiogenesis. The expression of PD-ECGF persists in endometriotic endometrium during the menstrual cycle. This might suggest that PD-ECGF contributes to the growth of ovarian endometriomas via subepithelial angiogenesis independently of the sex steroidal milieu.