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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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Manganese dipyridoxyl diphosphate: MRI contrast agent with antioxidative and cardioprotective properties?

H Brurok1, J H Ardenkjaer-Larsen, G Hansson

  • 1Department of Physiology and Biomedical Engineering, Faculty of Medicine, Norwegian University of Science and Technology, Medisinsk-Teknisk Senter, Trondheim, N-7005, Norway.

Biochemical and Biophysical Research Communications
|January 28, 1999
PubMed

Insights

Manganese dipyridoxyl diphosphate (MnDPDP), a liver MRI contrast agent, exhibits superoxide dismutase (SOD) mimetic activity. This antioxidant property protected rat hearts from oxidative stress in an ex vivo model.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Medical Imaging

Background:

  • Manganese dipyridoxyl diphosphate (MnDPDP) is an MRI contrast agent for liver imaging.
  • The potential antioxidant properties of MnDPDP have not been fully elucidated.

Purpose of the Study:

  • To investigate the in vitro superoxide dismutase (SOD) mimetic activity of MnDPDP.
  • To assess the ex vivo antioxidant protection offered by MnDPDP in a rat heart model.

Main Methods:

  • In vitro generation of superoxide and hydroxyl radicals using xanthine oxidase and Fenton reactions.
  • Detection of spin adducts via electron spin resonance (ESR) spectroscopy.
  • Ex vivo assessment of rat heart contractile function and enzyme release during hypoxia-reoxygenation.

Main Results:

  • MnDPDP and its metabolite MnPLED demonstrated SOD mimetic activity at low micromolar concentrations by dismutating superoxide radicals.
  • Neither compound showed activity in Fenton or catalase reactions.
  • MnDPDP (30 microM) significantly improved rat heart contractile function and reduced enzyme release during reoxygenation.

Conclusions:

  • MnDPDP and MnPLED possess significant SOD mimetic activities.
  • These compounds may offer cardioprotective effects against oxidative stress.

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