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Updated: Aug 17, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Oxidative stress and Parkinson's disease
T Ilić1, M Jovanović, A Jovicić
1Military Medical Academy, Department of Neurology, Belgrade.
Abstract:
The aim of this study was to determine the baseline state of oxidative stress indices in drug-naive patients with Parkinson's disease (PD). Cerebrospinal fluid (CSF) and peripheral blood samples of 31 subjects, in disease stages I-III, according to Hoehn & Yahr scale, were analyzed and compared with the control group. Highly significant increase of malondialdehyde content in CSF (p < 0.001) was found, as well as significant differences in peripheral blood parameters: malondialdehyde content was increased in patients with PD (p < 0.05), and also the activities of antioxidative defense enzymes, gluthathion reductase, Cu, Zn-superoxide-dismutase (p < 0.05), and the production of highly reactive oxygen species-superoxide radical (p < 0.05). Those findings indicated the important role of oxidative stress in Parkinson's disease evolution and progress. The findings of increased amount of reactive oxidative species (malondialdehyde content and superoxide radical production) in peripheral blood, and excessive activity of protective enzymatic systems (gluthathion reductase Cu, Zn-superoxid-dismutase) suggested the additional systemic reaction related to chronic oxidative stress state in the brain.
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