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Thrombomodulin levels in patients with coronary artery disease

H Mihara1, A Murai, K Handa

  • 1Department of Emergency and Critical Care Medicine, School of Medicine, Fukuoka University, Japan.

Artery
|January 1, 1997
PubMed

Insights

Serum thrombomodulin levels did not directly correlate with coronary artery disease in men. Elevated levels may indicate reduced kidney clearance, not necessarily atherosclerosis severity.

Area of Science:

  • Cardiology
  • Nephrology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Thrombomodulin (TM) plays a role in anticoagulation and inflammation.
  • The relationship between serum TM levels and CAD risk factors requires further elucidation.

Purpose of the Study:

  • To investigate the association between serum thrombomodulin levels and established coronary risk factors in men undergoing coronary angiography.
  • To explore the correlation between serum TM and the presence and severity of coronary atherosclerosis.
  • To determine if serum TM levels are associated with restenosis after percutaneous transluminal coronary angioplasty.

Main Methods:

  • Serum thrombomodulin levels were measured in 119 men undergoing coronary angiography.
  • Coronary risk factors including total cholesterol, hypertension, uric acid, and smoking were assessed.
  • Statistical analyses were performed to correlate serum TM levels with coronary atherosclerosis, risk factors, and restenosis.

Main Results:

  • Total cholesterol and hypertension were significantly higher in patients with coronary atherosclerosis.
  • Serum thrombomodulin levels were not significantly different between patients with and without coronary atherosclerosis.
  • Age, BUN, and creatinine were positively correlated with serum TM, while creatinine clearance was inversely correlated.

Conclusions:

  • Elevated serum thrombomodulin levels in patients with coronary artery disease may be attributed to decreased kidney clearance rather than direct association with atherosclerosis.
  • Serum TM levels are not a reliable indicator of coronary atherosclerosis severity or restenosis risk in this cohort.
  • Further research is needed to understand the role of kidney function in modulating serum thrombomodulin levels in cardiovascular disease.

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