Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Continuous heparinization and circulating adhesion molecules in the critically ill

J Boldt1, M Papsdorf, S N Piper

  • 1Department of Anesthesiology and Intensive Care Medicine, Klinikum der Stadt Ludwigshafen, Germany.

Shock (Augusta, Ga.)
|January 28, 1999
PubMed
Summary

Continuous heparinization did not reduce elevated adhesion molecules in trauma and sepsis patients. This suggests that heparin at this dosage may not impact endothelial inflammation or function in critically ill individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Does continuous heparinization influence platelet function in the intensive care patient?

Intensive care medicine·2023
Same author

Variation of Donor and Acceptor Strength in Analogues of Brooker's Merocyanine and Generalization to Various Classes of Charge Transfer Compounds.

The journal of physical chemistry. A·2019
Same author

Classification of skin sensitizing substances: a comparison between approaches used by the DFG-MAK Commission and the European Union legislation.

Regulatory toxicology and pharmacology : RTP·2011
Same author

Dual-wavelength heterodyne differential interferometer for high-precision measurements of reflective aspherical surfaces and step heights.

Applied optics·2010
Same author

Responses to iron limitation in Hordeum vulgare L. as affected by the atmospheric CO2 concentration.

Journal of environmental quality·2008
Same author

Designation of substances as skin sensitizing chemicals: a reply.

Human & experimental toxicology·2005

Area of Science:

  • Critical Care Medicine
  • Vascular Biology
  • Pharmacology

Background:

  • Endothelial activation and damage are key factors in multiple organ dysfunction syndrome (MODS).
  • Circulating adhesion molecules are indicators of endothelial activation and damage.

Purpose of the Study:

  • To investigate the effect of continuous intravenous unfractionated heparin on plasma levels of adhesion molecules in trauma and sepsis patients.
  • To determine if heparin administration can attenuate endothelial activation in critically ill patients.

Main Methods:

  • Prospective, randomized study involving 56 patients (28 trauma, 28 sepsis).
  • Patients received either unfractionated heparin (aiming for activated partial thromboplastin time (aPTT) ~2x normal) or no heparin.
  • Plasma levels of soluble endothelial leukocyte adhesion molecule-1 (sELAM-1), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (slCAM-1), and granule membrane protein-140 (sGMP-140) were measured over 5 days.

Related Experiment Videos

Main Results:

  • Plasma levels of all measured adhesion molecules increased in all patient groups.
  • The increase was most pronounced in sepsis patients, but not significantly different between heparin-treated and non-treated sepsis groups.
  • Trauma patients showed a less significant increase, with only sGMP-140 showing a significant difference between heparin and non-heparin subgroups.

Conclusions:

  • Continuous heparinization at approximately 600 U/h did not attenuate the rise in circulating adhesion molecules in trauma and sepsis patients.
  • The findings suggest that heparin, at this dosage, is unlikely to significantly influence endothelial inflammation or function in critically ill patients.