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Related Experiment Videos

Multiple sclerosis associated with uveitis in two large clinic-based series

V Biousse1, C Trichet, E Bloch-Michel

  • 1Department of Neurology, Lariboisière Hospital, Paris, France.

Neurology
|January 28, 1999
PubMed
Summary

Multiple sclerosis (MS) and uveitis co-occur in 1% of patients, with pars planitis and panuveitis being common. A significant delay often exists between neurological and ocular symptom onset, necessitating a sequential diagnostic approach.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Immunology

Background:

  • Uveitis is an inflammatory eye condition that can be associated with systemic autoimmune diseases.
  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • The co-occurrence of MS and uveitis requires careful diagnostic consideration.

Purpose of the Study:

  • To determine the prevalence of uveitis in patients with definite multiple sclerosis (MS).
  • To identify the types of uveitis most commonly associated with MS.
  • To analyze the temporal relationship between the onset of neurological and ocular symptoms in patients with both conditions.

Main Methods:

  • Retrospective review of patient records from a dedicated MS clinic (n=1,098) and a uveitis clinic (n=1,530).

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  • Inclusion criteria required a diagnosis of definite MS and uveitis.
  • Prevalence, types of uveitis, and symptom onset timelines were analyzed.

    • Main Results:

    • A total of 28 patients (1% of 2,628) were identified with both definite MS and uveitis.
    • Prevalence was 1.1% in the MS clinic cohort and 1% in the uveitis clinic cohort.
    • Pars planitis and panuveitis were the most frequent types of uveitis observed, with a mean delay of 9 years between neurological and ocular symptom onset.

    Conclusions:

    • Uveitis affects approximately 1% of patients with definite MS.
    • Pars planitis and panuveitis are the predominant forms of ocular inflammation in this population.
    • The substantial delay between symptom onset highlights the need for a high index of suspicion and sequential diagnostic evaluation in patients with MS and unexplained ocular symptoms.