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A cross-sectional study on the relationship between depression and left ventricular hypertrophy

Y Takemura1, S Kikuchi, H Takagi

  • 1Department of Epidemiology and Environmental Health, Juntendo University School of Medicine, Tokyo, Japan.

Preventive Medicine
|January 28, 1999
PubMed

Insights

High depression levels are linked to a greater risk of left ventricular hypertrophy (LVH), a heart condition. This finding suggests depression may be a factor in cardiovascular disease prevention.

Area of Science:

  • Cardiology
  • Psychiatry
  • Preventive Medicine

Background:

  • The link between depression and cardiovascular disease (CVD) is not fully understood.
  • Left ventricular hypertrophy (LVH), detected by electrocardiogram (ECG), is a significant CVD risk factor.
  • This study explores the novel association between depression and ECG-detected LVH.

Purpose of the Study:

  • To investigate the relationship between depression and left ventricular hypertrophy (LVH).
  • To determine if depression is an independent risk factor for LVH in middle-aged men.

Main Methods:

  • 346 male participants aged 49-55 from Japan Self-Defense Forces.
  • Assessment of LVH using electrocardiogram (ECG).
  • Measurement of depression via the Self-Rating Depression Scale (SDS).
  • Logistic regression analysis adjusted for BMI, systolic, and diastolic blood pressure.

Main Results:

  • A high depression level (SDS score ≥ 34) was associated with an increased risk of LVH.
  • A trend towards a positive association between LVH and high depression levels persisted after adjusting for cardiovascular risk factors.

Conclusions:

  • Depression is closely associated with left ventricular hypertrophy (LVH).
  • LVH is a predictor of fatal cardiovascular events, highlighting the importance of managing depression for heart health.
  • Findings support the integration of mental health screening and intervention in cardiovascular disease prevention strategies.
Abstract

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