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Changes in integrin/adhesion molecule expression, but not in the T-cell receptor repertoire, in old mice infected
1Department of Microbiology, Colorado State University, Fort Collins 80523, USA.
The results of this study present data in support of the hypothesis that T lymphocytes in both young and old mice infected with virulent Mycobacterium tuberculosis undergo changes in expression of cell surface integrin/adhesion molecules as determined by flow cytometric analysis. These data thus further support the hypothesis that a reduced ability of T-cells in old mice to adequately and promptly accumulate at sites of inflammation induced by bacterial implantation is a central parameter underlying the increased susceptibility of these mice to this intracellular bacterial infection. In addition, however, no changes were observed in terms of the T-cell receptor expression (repertoire) of these animals, indicating that this facet of immunity is preserved in aging.
The results of this study present data in support of the hypothesis that T lymphocytes in both young and old mice infected with virulent Mycobacterium tuberculosis undergo changes in expression of cell surface integrin/adhesion molecules as determined by flow cytometric analysis. These data thus further support the hypothesis that a reduced ability of T-cells in old mice to adequately and promptly accumulate at sites of inflammation induced by bacterial implantation is a central parameter underlying the increased susceptibility of these mice to this intracellular bacterial infection. In addition, however, no changes were observed in terms of the T-cell receptor expression (repertoire) of these animals, indicating that this facet of immunity is preserved in aging.