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Lymphomas in solid organ transplantation

D A Lee1, R P Hartman, S W Trenkner

  • 1Department of Radiology, University of Minnesota, Minneapolis 55455, USA.

Abdominal Imaging
|January 28, 1999
PubMed
Summary
This summary is machine-generated.

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Post-transplant lymphoma, particularly abdominal lymphomas, occurs in 1% of solid-organ-transplant recipients. Many patients present with Epstein-Barr virus and aggressive disease, often leading to fatal outcomes.

Area of Science:

  • Oncology
  • Transplantation Medicine
  • Immunology

Background:

  • Solid organ transplantation significantly increases lymphoma risk compared to the general population.
  • Post-transplant lymphoproliferative disorders (PTLD) are a serious complication in transplant recipients.
  • Abdominal lymphomas represent a specific and challenging manifestation of PTLD.

Purpose of the Study:

  • To identify and characterize abdominal lymphomas in a large cohort of solid-organ-transplant recipients.
  • To understand the incidence and clinical presentation of abdominal PTLD.
  • To analyze risk factors and outcomes associated with abdominal PTLD.

Main Methods:

  • Retrospective analysis of a large solid-organ-transplant population.
  • Identification of all patients who developed abdominal lymphoma post-transplantation.

Related Experiment Videos

  • Detailed review of medical records and radiological examinations for characterization.

    • Main Results:

    • Lymphoma developed in 28 (1%) of 2925 transplant patients.
    • 14 patients (48%) presented with abdominal manifestations of lymphoma.
    • Epstein-Barr virus positivity and cyclosporine treatment were common; most patients succumbed to the disease.

    Conclusions:

    • Abdominal lymphoma is a significant concern in solid organ transplantation.
    • Half of the post-transplant lymphoma cases in this cohort manifested abdominally.
    • Early identification and characterization are crucial for managing this aggressive complication.