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Myocardial Infarction and Functional Outcome Assessment in Pigs
12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

Angiographic frame counts 90 minutes after streptokinase predict left ventricular function at 48 hours following

J K French1, I T Straznicky, B J Webber

  • 1Department of Cardiology, Green Lane Hospital, Private Bag 92189, Auckland 1030, New Zealand. johnf@ahsl.co.nz

Heart (British Cardiac Society)
|January 29, 1999
PubMed

Insights

The 90-minute corrected thrombolysis in myocardial infarction frame count (CTFC) predicts heart function after treatment. Higher CTFC values indicate better left ventricular function post-myocardial infarction.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Imaging

Background:

  • Myocardial infarction (MI) treatment aims to restore blood flow and preserve left ventricular (LV) function.
  • Early assessment of reperfusion and its impact on LV function is crucial for patient outcomes.

Purpose of the Study:

  • To determine if the 90-minute corrected thrombolysis in myocardial infarction frame count (CTFC) in the infarct-related artery predicts LV function at 48 hours.
  • To evaluate the predictive value of CTFC in patients receiving aspirin, streptokinase, and either heparin or Hirulog.

Main Methods:

  • Analysis of 251 patients from the HERO-1 trial with acute MI.
  • Coronary angiography performed at 90 minutes to calculate CTFC in the infarct-related artery.
  • Left ventriculography at 48 hours to assess LV function (ejection fraction, end-systolic volume, infarct zone score).

Main Results:

  • A CTFC ≤ 40 frames at 90 minutes was associated with significantly better LV function at 48 hours.
  • This included a lower mean chord score, smaller fraction of chords below normal, smaller end-systolic volume, and higher LV ejection fraction.
  • A CTFC ≤ 27 frames also showed trends towards improved LV function.

Conclusions:

  • The 90-minute CTFC is a reliable predictor of left ventricular function 48 hours after streptokinase treatment for myocardial infarction.
  • The optimal CTFC threshold for predicting better ventricular function may be higher than previously established values from non-infarct populations.
Abstract

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