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Intracellular CFTR: localization and function

N A Bradbury1

  • 1Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pennsylvania, USA.

Physiological Reviews
|January 29, 1999
PubMed
Summary

Cystic fibrosis transmembrane conductance regulator (CFTR) is found in intracellular organelles, suggesting roles beyond its known function as a plasma membrane chloride channel. This review explores CFTR

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Area of Science:

  • Cell Biology
  • Physiology
  • Molecular Biology

Background:

  • Cystic fibrosis transmembrane conductance regulator (CFTR) is primarily known as a chloride-selective channel in the apical membrane of epithelial cells.
  • CFTR's role in cystic fibrosis pathogenesis is linked to its apical membrane function, but its presence in intracellular compartments is increasingly recognized.

Purpose of the Study:

  • To review the evidence for CFTR localization within intracellular organelles.
  • To explore the potential physiological functions of intracellular CFTR.

Main Methods:

  • Literature review of studies investigating CFTR localization and function.
  • Analysis of experimental data supporting intracellular CFTR roles.

Main Results:

  • CFTR is present in various intracellular compartments, including the endoplasmic reticulum, Golgi, endosomes, and lysosomes.
  • Evidence suggests intracellular CFTR functions in organelle acidification, membrane trafficking, and anion transport.

Conclusions:

  • CFTR's intracellular localization implies roles beyond apical membrane ion transport.
  • Understanding intracellular CFTR function may offer new insights into cystic fibrosis and other cellular processes.

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