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Intima-media thickness of carotid arteries in borderline hypertensives

J Pit'ha1, D Krajícková, R Cífková

  • 1Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|January 29, 1999
PubMed

Insights

Body mass index (BMI) and HDL-cholesterol levels significantly impact atherosclerosis progression in borderline hypertensive patients. These cardiovascular disease risk factors are key to understanding subclinical atherosclerosis development.

Area of Science:

  • Cardiovascular Medicine
  • Medical Imaging
  • Genetics

Background:

  • Subclinical atherosclerosis is a precursor to cardiovascular disease.
  • Borderline hypertension is a critical stage for early intervention.
  • Identifying key risk factors is crucial for preventing cardiovascular events.

Purpose of the Study:

  • To evaluate the influence of major cardiovascular disease risk factors on subclinical atherosclerosis.
  • To analyze the relationship between common carotid artery intima-media thickness (IMT CCA) and various risk factors in borderline hypertensives.

Main Methods:

  • B-mode ultrasound was used to measure far wall common carotid artery intima-media thickness (IMT CCA).
  • Analysis included smoking status, body mass index (BMI), blood pressure, lipid profiles, and angiotensin-converting enzyme (ACE) gene polymorphism.
  • Subjects were stratified into tertiles based on IMT CCA for comparative analysis.

Main Results:

  • Significant differences in BMI and HDL-cholesterol were observed between the lowest and highest IMT CCA tertiles.
  • No significant associations were found between IMT CCA and blood pressure, total cholesterol, triacylglycerols, smoking, or ACE gene polymorphism.
  • These findings highlight the role of BMI and HDL-cholesterol in atherosclerosis within this patient cohort.

Conclusions:

  • Body mass index (BMI) and HDL-cholesterol levels are significant determinants of subclinical atherosclerosis in borderline hypertensives.
  • Further research should focus on managing BMI and HDL-cholesterol to mitigate atherosclerosis progression.
  • The study underscores the importance of lipid profiles and weight management in cardiovascular risk assessment.

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