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Related Experiment Videos

Laboratory evaluation of hypercoagulable states

E M Van Cott1, M Laposata

  • 1Coagulation Laboratory, Massachusetts General Hospital, Boston, USA.

Hematology/Oncology Clinics of North America
|January 29, 1999
PubMed
Summary

Hypercoagulable conditions, both inherited and acquired, are increasingly identified in patients with thrombophilia. This review details these states, their associated thrombosis risks, and diagnostic testing recommendations.

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Area of Science:

  • Hematology
  • Clinical Pathology
  • Genetics

Background:

  • The identification of hereditary and acquired hypercoagulable conditions is growing.
  • Many patients with thrombophilia can now have a specific hypercoagulable condition identified by laboratory testing.

Purpose of the Study:

  • To review known hypercoagulable states.
  • To discuss their predisposition to venous and arterial thrombosis.
  • To summarize recommendations for laboratory testing.

Main Methods:

  • Literature review of hypercoagulable states.
  • Analysis of incidence and thrombotic risk.
  • Evaluation of synergistic interactions and molecular pathogenesis.
  • Summary of laboratory test interpretation and recommendations.

Main Results:

  • Detailed descriptions of various hypercoagulable conditions.
  • Comparison of thrombotic risk in the general population versus symptomatic families.
  • Insights into synergistic interactions between different hypercoagulable states.
  • Guidance on interpreting laboratory test results for hypercoagulable disorders.

Conclusions:

  • Clinicians can now identify specific hypercoagulable conditions in many thrombophilic patients.
  • Understanding these conditions is crucial for managing thrombosis risk.
  • Standardized laboratory testing recommendations are provided.

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