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Updated: Aug 15, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
NMR studies of DNA duplexes containing alpha-anomeric nucleotides and polarity reversals
1Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Abstract:
We present a summary of our research to date on a family of self-complementary DNA decamers containing single alpha-anomeric nucleotides flanked by 3'-3' and 5'-5' phosphodiester linkages from the perspective of the salient NMR techniques employed to shed light on the structural and dynamic properties of these sequences. Research into this class of synthetic alpha-/beta-oligonucleotides containing mixed strand disposition may have medical relevance given their recently documented efficacy as antisense therapeutics.
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