Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac magnetic resonance spectroscopy

R Deslauriers1, V V Kupriyanov

  • 1Institute for Biodiagnostics, National Research Council of Canada, Winnipeg, MB. deslauriers@ibd.nrc

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|January 29, 1999
PubMed
Summary

Cardiac magnetic resonance spectroscopy (MRS) in Canada offers insights into heart energetics, ion balance, and metabolic changes. Various MRS techniques and animal models are used to study cardiac function under normal and stressed conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The method of noncovalent in vitro binding of target proteins to virus-like nanoparticles formed by core antigen of hepatitis B virus.

Doklady. Biochemistry and biophysics·2013
Same author

Manganese-enhanced MRI of acute cardiac ischemia and chronic infarction in pig hearts: kinetic analysis of enhancement development.

NMR in biomedicine·2008
Same author

Adrenergic stimulation of Rb+ uptake in pig hearts in vivo assessed by 87Rb MRS.

Magnetic resonance in medicine·2005
Same author

Imaging of ischemia and infarction in blood-perfused pig hearts using 87Rb MRI.

Magnetic resonance in medicine·2003
Same author

Effect of adrenergic stimulation on Rb(+) uptake in normal and ischemic areas of isolated pig hearts: (87)Rb MRI study.

Magnetic resonance in medicine·2002
Same author

Effects of regional hypoxia and acidosis on Rb(+) uptake and energetics in isolated pig hearts: (87)Rb MRI and (31)P MR spectroscopic study.

Biochimica et biophysica acta·2002

Area of Science:

  • Cardiovascular Research
  • Biophysics
  • Medical Imaging

Background:

  • Cardiac magnetic resonance spectroscopy (MRS) is a non-invasive technique for assessing heart metabolism and function.
  • Previous studies have utilized various MRS isotopes and models to investigate cardiac physiology and pathology.

Purpose of the Study:

  • To review the applications of cardiac magnetic resonance spectroscopy (MRS) in Canada.
  • To highlight the utility of different MRS techniques (31P, 23Na, 87Rb, 7Li, 1H) in studying cardiac energetics, ion balance, and metabolic adaptations.
  • To discuss the use of various animal and human tissue models in cardiac MRS research.

Main Methods:

  • Utilized phosphorus-31 (31P) MRS to study cardiac energetics and intracellular pH during ischemia-reperfusion.

Related Experiment Videos

  • Employed sodium-23 (23Na), rubidium-87 (87Rb), and lithium-7 (7Li) MRS to investigate ion balance and fluxes.
  • Applied proton (1H) MRS to monitor lactate and lipid accumulation and assess dietary effects on cardiac lipids.
  • Reviewed studies using isolated rat and pig hearts, human atrial appendages, and in vivo canine and human models.

    • Main Results:

    • 31P MRS effectively evaluated cardiac energetics and pH changes in response to ischemia-reperfusion and pharmacological interventions.
    • 23Na, 87Rb, and 7Li MRS provided unique insights into ion dynamics under physiological stress.
    • 1H MRS tracked metabolic changes like lactate and lipid accumulation, and diet-induced alterations.
    • Animal models (rat, pig) and human tissues (atrial appendages) demonstrated utility in studying cardiac preservation and function.

    Conclusions:

    • Cardiac MRS is a versatile tool for investigating cardiac energetics, ion homeostasis, and metabolic pathways.
    • Different MRS nuclei and experimental models offer complementary approaches to understand cardiac health and disease.
    • Research in Canada using cardiac MRS contributes to advancing cardiovascular diagnostics and therapeutics.