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Related Experiment Videos

Gefarnate increases PAS positive cell density in rabbit conjunctiva

M Nakamura1, K Endo, K Nakata

  • 1Nara Research and Development Center, Santen Pharmaceutical Co, Ltd, Japan.

The British Journal of Ophthalmology
|January 30, 1999
PubMed
Summary

Gefarnate eye drops significantly increased periodic acid Schiff (PAS) positive cells in rabbit conjunctiva. Other gastritis drugs, ecabet sodium and troxipide, did not affect PAS cell density.

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Area of Science:

  • Ophthalmology
  • Gastroenterology
  • Cell Biology

Background:

  • Gastritis and gastric ulcers are common conditions.
  • Current treatments include gefarnate, ecabet sodium, and troxipide.
  • The ocular effects of these drugs are not well understood.

Purpose of the Study:

  • To investigate the effects of gefarnate, ecabet sodium, and troxipide on periodic acid Schiff (PAS) positive cell density in rabbit conjunctiva.
  • To determine if these drugs, used for gastrointestinal conditions, have any impact on ocular surface cells.

Main Methods:

  • Rabbit eyes were treated with eye drops containing gefarnate, ecabet sodium, or troxipide at varying concentrations (0.1%, 1%) for 7 days.
  • Impression cytology with PAS staining was performed on the conjunctiva.

Related Experiment Videos

  • PAS-positive cells were quantified in selected areas of the conjunctival specimens.

    • Main Results:

    • Gefarnate at a 1% concentration significantly increased PAS-positive cell density in the conjunctiva (p < 0.05).
    • Ecabet sodium and troxipide did not significantly alter PAS-positive cell density at the tested concentrations.
    • This suggests a specific effect of gefarnate on conjunctival cells.

    Conclusions:

    • Gefarnate demonstrates a stimulatory effect on PAS-positive cell density in rabbit conjunctiva.
    • This finding indicates a potential biological activity of gefarnate on the ocular surface.
    • Further research may explore the clinical implications of gefarnate's effect on conjunctival cells.