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Related Experiment Videos

CART, a new anorectic peptide

L Thim1, P Kristensen, P J Larsen

  • 1Novo Nordisk A/S, Bagsvaerd, Denmark. lth@novo.dk

The International Journal of Biochemistry & Cell Biology
|January 30, 1999
PubMed
Summary

Cocaine and amphetamine regulated transcript peptide (CART) is a novel hypothalamic peptide that powerfully suppresses appetite. Its central nervous system expression and regulation by leptin suggest CART is a key player in feeding behavior.

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Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Obesity Research

Background:

  • Cocaine and amphetamine regulated transcript peptide (CART) is a recently identified hypothalamic peptide.
  • CART exhibits potent appetite-suppressing activity.
  • The CART gene encodes different peptide lengths in rats versus humans.

Purpose of the Study:

  • To investigate the role of CART in regulating feeding behavior.
  • To explore CART as a potential therapeutic target for obesity.

Main Methods:

  • Analysis of CART gene and peptide structure.
  • Examination of CART expression in the central nervous system.
  • Investigation of CART mRNA regulation by leptin.

Main Results:

Related Experiment Videos

  • CART is highly expressed in hypothalamic nuclei involved in feeding regulation.
  • CART mRNA levels are influenced by leptin.
  • Expressed CART potently inhibits feeding, overriding neuropeptide Y effects.

Conclusions:

  • CART is a significant inhibitor of feeding behavior.
  • The CART receptor represents a potential therapeutic target for anti-obesity drugs.