Lack of association between juvenile myoclonic epilepsy and HLA-DR13
S Le Hellard1, E Neidhart, P Thomas
1Division de Neuropsychiatrie, Hôpitaux Universitaires de Genève, Belle-Idée, Chêne Bourg, Switzerland.
Purpose:
We sought to replicate and extend a previously reported positive association between juvenile myoclonic epilepsy and HLA-DR13.
Methods:
Ninety-three subjects with juvenile myoclonic epilepsy and 93 normal blood donors, entirely of white origin with their families mostly of French extraction, underwent DNA-based HLA-DR13 and DQB6 typing.
Results:
None of the investigated alleles or combination of alleles (DRB1*1301-DQB1*0603 or DRB1*1302-DQB1*0604) showed a significant difference between patients and controls.
Conclusions:
Unlike previously reported positive association, in this population, there is no evidence that susceptibility to juvenile myoclonic epilepsy is associated with HLA-DR13.
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