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Evaluation of the cytotoxic activity of polyethers isolated from Laurencia
J J Fernández1, M L Souto, M Norte
1Instituto Universitario de Bio-Orgánica, Universidad de La Laguna, Astrofísico Francisco Sánchez, Tenerife, Spain.
Bioorganic & Medicinal Chemistry
|January 30, 1999
Abstract:
In this paper, we report on the conformational analysis of several polyether triterpenes with a squalene carbon skeleton which exhibited significant cytotoxic activity using a Monte Carlo conformational search and spectroscopical data. These studies indicate that the conformation of the side chain C-14/C-19 and the arrangement and direction of this chain may be among the fundamental factors related to the activity of this type of metabolites.