[Effectiveness of nuclear medicine kidney clearance procedure]

Methods and clinical indications of divided renal clearance determination using 131I-hippuran are presented and their value as a diagnostic tool in urology is shown by two case reports. For quantitative assessment of renal function we prefer the whole body clearance (with partial shielding of kidneys and bladder), which obviates the necessity of the theoretical assumption of compartmental distribution of radiopharmaceuticals. Using simplified clearance tecniques only based on analysis of plasma disappearance curves (slope clearance one- and two-compartment model), clinically useful results are also obtainable, especially in follow up studies. The evaluation of tubular and glomerular kidney function by simultaneous application of 131I-hippuran and 99mTc-DTPA is suitable for estimation of filtration fraction in patients with urological and nephrological diseases. Even with regard to therapy and follow up studies of urinary tract tuberculosis, remarkable diagnostic informations may be achieved.