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Fungal lethality, binding, and cytotoxicity of syringomycin-E
A J De Lucca1, T J Jacks, J Takemoto
1Southern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, New Orleans, Louisiana 70124, USA. adelucca@nola.srrc.usda.gov
Antimicrobial Agents and Chemotherapy
|January 30, 1999
Abstract:
Syringomycin-E (SE) was significantly lethal to Aspergillus and Fusarium species at between 1.9 and 7.8 micrograms/ml. SE complexed with the following fungal wall constituents (in order of binding): beta-1,3-glucan > chitin > mannan > ergosterol = cholesterol. Cytotoxicity in HeLa cells was proportional to the SE concentration, while the amount required for cytotoxicity was 3 to 20 times that needed to kill 95% of the fungi tested.