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Elevated glycated haemoglobin in non-diabetic patients is associated with an increased mortality in myocardial

T A Chowdhury1, S S Lasker

  • 1Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK.

Postgraduate Medical Journal
|February 2, 1999
PubMed

Insights

Elevated glycated haemoglobin (HbA1c) levels are a significant risk factor for death after acute myocardial infarction, even in non-diabetic individuals. This finding highlights HbA1c as a crucial marker for short-term mortality risk.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Diabetes mellitus is linked to higher mortality rates post-acute myocardial infarction (AMI).
  • Elevated glycated haemoglobin (HbA1c) in diabetic patients correlates with increased AMI mortality.
  • Mild HbA1c elevations can indicate impaired glucose tolerance.

Purpose of the Study:

  • To investigate the impact of HbA1c on AMI outcomes in non-diabetic patients.
  • To identify HbA1c as a potential risk marker in this population.

Main Methods:

  • Study included 253 non-diabetic patients experiencing AMI.
  • Univariate and logistic regression analyses were performed.
  • Risk factors for one-year mortality were assessed, including HbA1c, glucose, cholesterol, and smoking status.

Main Results:

  • A total of 46 patients died within one year.
  • Univariate analysis identified smoking, glucose, cholesterol, and HbA1c as risk factors for death.
  • Logistic regression confirmed HbA1c as an independent risk factor for mortality.
  • The highest HbA1c quartile was more prevalent in the non-surviving group (over one-third) compared to survivors (one-fifth).

Conclusions:

  • Elevated HbA1c serves as a significant risk marker for short-term mortality following acute myocardial infarction in individuals without diabetes.
  • HbA1c monitoring may be valuable for risk stratification in non-diabetic AMI patients.

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