Treatment of grey zone lymphomas

The inability of distinguishing difficult cases of Hodgkin's disease from non-Hodgkin's lymphoma has been a long-standing problem. Initially, the controversy centered on lymphocyte-depleted Hodgkin's disease; now with improved diagnostic techniques, most controversy centers around the anaplastic large-cell lymphomas. These problematic cases may also represent a less frequent problem, although data on this point is difficult to obtain. The future controversy may well involve the separation of T-cell rich B-cell lymphoma and Hodgkin's disease, nodular paragranuloma type. Fortunately, to date the clinical data does not support that there is a major difference in therapeutic results depending on whether these cases are treated as Hodgkin's disease or non-Hodgkin's lymphoma.