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The effect of povidone-iodine on thyroid function of neonates with different birth sizes
Insights
Povidone-iodine (PV-I) application can elevate TSH levels in very-low-birth weight (VLBW) newborns, impacting thyroid function. Avoid widespread PV-I use on VLBW infants, regardless of local iodine intake.
Area of Science:
- Neonatal endocrinology
- Pediatric dermatology
- Clinical pharmacology
Background:
- Povidone-iodine (PV-I) is a common antiseptic used in neonatal care.
- High iodine intake areas may influence newborn thyroid function.
- The impact of PV-I on thyroid function in newborns of varying birth weights is not fully understood.
Purpose of the Study:
- To investigate the effect of povidone-iodine (PV-I) on thyroid function in newborns.
- To assess differences based on birth weight and local iodine intake.
- To determine the safety of PV-I in neonatal care.
Main Methods:
- Serial measurements of serum thyroxine (T4) and thyrotropin (TSH) were performed.
- Study included 44 newborns treated with 10% PV-I for central venous catheter insertion.
- Newborns were categorized by birth size, including very-low-birth weight (VLBW) infants.
Main Results:
- PV-I application significantly increased TSH levels in VLBW infants after 48 hours.
- Thyroid function was notably influenced in VLBW neonates.
- Lower birth weight correlated with lower T4 levels at birth and subsequently.
Conclusions:
- Povidone-iodine (PV-I) application should be avoided on extensive skin surfaces in VLBW newborns.
- This recommendation holds true even in regions with high iodine intake.
- Careful consideration of PV-I use is warranted in vulnerable neonatal populations.
Abstract:
The aim of this study was to elucidate the role of povidone-iodine (PV-I) on thyroid function of newborns with different birth sizes in a high iodine-intake city. Serial measurements of serum thyroxine (T4) and thyrotropin (TSH) levels were done in 44 newborns locally treated with 10% PV-I for insertion of percutaneous central venous catheters. The results showed that the thyroid function was influenced prominently in very-low-birth weight (VLBW) babies. TSH went significantly higher after application of PV-I for 48 hours in VLBW babies. The smaller the babies were, the lower the T4 at birth and thereafter. In conclusion, PV-I is suggested to be avoided for single application on a wide skin surface in VLBW babies, even in an area with high iodine-intake population.