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Published on: April 9, 2012
Risk factors for rifampin-monoresistant tuberculosis: A case-control study
L Sandman1, N W Schluger, A L Davidow
1Division of Pulmonary and Critical Care Medicine, Department of Environmental Medicine, New York University School of Medicine, New York, USA.
American Journal of Respiratory and Critical Care Medicine
|February 2, 1999
Summary
Rifampin-monoresistant tuberculosis (RMR-TB) primarily affects individuals with prior tuberculosis (TB) history and HIV positivity. These patients often have poor outcomes, including higher mortality rates.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Rifampin is a critical drug for tuberculosis (TB) treatment.
- Rifampin monoresistance (RMR) is less prevalent than other forms of drug resistance in TB.
- Identifying risk factors for RMR-TB is crucial for effective treatment strategies.
Purpose of the Study:
- To identify risk factors associated with rifampin monoresistance in tuberculosis (TB).
- To compare characteristics of patients with RMR-TB to those with drug-susceptible TB.
Main Methods:
- A retrospective case-control study was conducted.
- 21 patients with RMR-TB were compared to 48 patients with drug-susceptible TB.
- Data were analyzed controlling for year of diagnosis and HIV status.
Main Results:
- RMR-TB patients were more likely to have a history of TB (61% vs. 22%) and HIV positivity (81% vs. 46%).
- Extrapulmonary involvement (47.6% vs. 11.6%) and mortality during hospitalization (19% vs. 2.1%) were higher in RMR-TB cases.
- History of incarceration (71.4% vs. 37.5%) and malabsorption symptoms were more frequent in RMR-TB patients.
Conclusions:
- Rifampin monoresistance is strongly associated with a history of TB and HIV co-infection.
- Factors such as noncompliance, incarceration history, and malabsorption may contribute to RMR-TB.
- RMR-TB is linked to poorer patient outcomes and increased mortality.
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