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Left ventricular diastolic function in normal human pregnancy

A Mesa1, C Jessurun, A Hernandez

  • 1Department of Cardiology, St Luke's Episcopal Hospital and Baylor College of Medicine, Texas Heart Institute, Houston, USA.

Circulation
|February 2, 1999
PubMed
Summary
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Pregnancy significantly alters diastolic function, increasing early filling (E) and atrial contraction (A) velocities. These changes in mitral inflow and pulmonary venous flow provide a reference for diastolic filling dynamics during pregnancy.

Area of Science:

  • Cardiology
  • Physiology
  • Obstetrics

Background:

  • Limited data exists on left ventricular diastolic function changes during pregnancy.
  • Pregnancy is a natural volume-overload state impacting cardiovascular hemodynamics.

Purpose of the Study:

  • To evaluate left ventricular diastolic function during pregnancy using mitral inflow and pulmonary venous flow.
  • To establish a reference for diastolic filling dynamics across pregnancy trimesters.

Main Methods:

  • Echocardiography was used to assess mitral inflow and pulmonary venous flow in 37 healthy pregnant women.
  • Studies were conducted at the end of each trimester, with a control group assessed postpartum.

Main Results:

  • Cardiac output increased due to elevated heart rate and stroke volume.

Related Experiment Videos

  • Systemic vascular resistance decreased, and left ventricular mass increased.
  • Mitral inflow velocities (E and A) and the E/A ratio changed significantly across trimesters, as did pulmonary venous flow patterns.

    • Conclusions:

    • Pregnancy induces significant hemodynamic and echocardiographic changes affecting diastolic function.
    • Pulmonary venous flow and left ventricular inflow velocities offer a standard reference for diastolic filling dynamics during pregnancy.