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The nuclear matrix prepared by amine modification

K M Wan1, J A Nickerson, G Krockmalnic

  • 1Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

Proceedings of the National Academy of Sciences of the United States of America
|February 3, 1999
PubMed
Summary

Researchers developed a new method to isolate the nuclear matrix by chemically modifying chromatin, enabling its removal at physiological ionic strength. This technique preserves the nuclear matrix's native structure for better cellular architecture studies.

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