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Enhancement of systemic and pulmonary vasoconstriction by beta-amyloid peptides and its suppression by vasoactive
S I Said1, S Raza, H I Berisha
1Department of Veterans Affairs Medical Center, Northport, New York, USA. SSAID@EPO.SOM.SUNYSB.EDU
Annals of the New York Academy of Sciences
|February 3, 1999
Abstract:
(1) A beta peptides potentiate vasoconstriction, caused by norepinephrine, and possibly other endogenous vasoconstrictors. If this potentiation occurs in the cerebral circulation, close to sites of A beta deposition in AD brains, the enhanced vasoconstriction could result in neuronal ischemia and death. (2) By neutralizing this deleterious effect of A beta, and through other neuroprotective mechanisms, VIP may provide an important defense against neuronal loss in AD.