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A selenium-containing abzyme, the activity of which surpassed the level of native glutathione peroxidase
1National Laboratory of Enzyme Engineering, Jilin University, Changchun, China.
Annals of the New York Academy of Sciences
|February 3, 1999
Abstract:
Using two different glutathione derivatives as hapten, we have prepared two abzymes, which display glutathione peroxidase (GPX) activity. Their GPX activities are 0.2 and 1.6 times that of natural GPX from rabbit liver, respectively. Selenium content analysis indicates that the activity difference between the two abzymes is possibly attributed to the conformation difference of the abzymes.