Related Experiment Videos
Identification of the autoantigen of celiac disease
D Schuppan1, W Dieterich, T Ehnis
1Free University of Berlin, Klinikum Benjamin Franklin, Department of Gastroenterology, Germany. detlef.schuppan@med1.med.uni-erlangen.de
Annals of the New York Academy of Sciences
|February 3, 1999
Abstract:
Tissue transglutaminase is demonstrated to be the unknown endomysial autoantigen by means of immunoprecipitations from a fibrosarcoma cell culture. A novel hypothesis for the pathogenesis of celiac disease is formulated: The mainly intracellular tissue transglutaminase is released from cells during wound healing where it aids in stabilizing the wound area by cross-linking a small set of extracellular matrix components.