Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV/SIV enteropathy

M Zeitz1, R Ullrich, T Schneider

  • 1University of the Saarland, Homburg/Saar, Germany. inmzei@med-rz.uni-sb.de

Annals of the New York Academy of Sciences
|February 3, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity negatively impacts outcome in elderly female patients with aggressive B-cell lymphomas treated with R-CHOP: results from prospective trials of the German high grade non-Hodgkin's lymphoma trial group.

British journal of haematology·2017
Same author

Excellent outcome of young adults with aggressive non-Hodgkin lymphomas treated with CHOP-like regimens.

Leukemia·2014
Same author

Transformation and additional malignancies are leading risk factors for an adverse course of disease in marginal zone lymphoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2013
Same author

Immunoassay for detection of IgA antitissue transglutaminase in patients with celiac disease.

Methods in molecular medicine·2011
Same author

Retrospective web-based multicenter evaluation of ¹⁸F-FDG-PET and CT derived predictive factors. Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan in follicular non Hodgkin's lymphoma.

Nuklearmedizin. Nuclear medicine·2010
Same author

Radioimmunotherapy with (90)Y-ibritumomab tiuxetan is a safe and efficient treatment for patients with B-cell lymphoma relapsed after auto-SCT: an analysis of the international RIT-Network.

Bone marrow transplantation·2010
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

HIV/SIV infection rapidly depletes CD4+ T-cells in the gut, leading to immunodeficiency and gastrointestinal issues. Mucosal T-cell loss influences whether gut damage is hypoproliferative or hyperproliferative.

Area of Science:

  • Immunology
  • Gastroenterology
  • Virology

Background:

  • HIV/SIV infection significantly impacts the gut-associated immune system, contributing to gastrointestinal pathology.
  • Early and pronounced loss of CD4+ T-cells occurs in the gut mucosa compared to peripheral blood during HIV/SIV infection.
  • Mucosal immunodeficiency resulting from T-cell depletion can lead to opportunistic infections.

Purpose of the Study:

  • To investigate the role of the gut-associated immune system in HIV/SIV pathogenesis.
  • To understand the mechanisms behind gastrointestinal manifestations in HIV/SIV infection.
  • To differentiate between early and late-stage enteropathy in immunodeficiency virus infection.

Main Methods:

  • Comparative analysis of CD4+ T-cell loss in gut mucosa versus peripheral blood in HIV/SIV-infected individuals and nonhuman primates.

Related Experiment Videos

  • Histopathological examination of small intestinal tissue to assess villous atrophy, epithelial cell regeneration, and maturation.
  • Correlation of T-cell status with observed enteropathic changes.

    • Main Results:

    • A rapid and significant loss of CD4+ T-cells in the gut mucosa is a hallmark of early HIV/SIV infection.
    • Small intestinal damage (enteropathy), including villous atrophy, occurs independently of secondary infections.
    • Early-stage SIV enteropathy in macaques shows villous atrophy with crypt cell hyperproliferation, while late-stage human HIV enteropathy exhibits villous atrophy with hyporegeneration and dysmaturation.

    Conclusions:

    • HIV/SIV-induced mucosal CD4+ T-cell depletion is central to gastrointestinal pathogenesis.
    • Enteropathy in immunodeficiency virus infection can manifest in distinct forms (hypo- vs. hyperproliferative villous atrophy).
    • The number and activation state of regulatory T-cells likely dictate the type of mucosal transformation observed in enteropathy.