Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mitochondrial aging: open questions

K B Beckman1, B N Ames

  • 1Department of Molecular and Cell Biology, University of California, Berkeley 94720-3202, USA. kbeckman@uclink4.berkeley.edu

Annals of the New York Academy of Sciences
|February 3, 1999
PubMed
Summary

Mitochondria play a key role in aging, with oxidative damage from the electron transport chain contributing to senescence. Mitochondrial DNA mutations and dysfunction increase with age, impacting cellular health and lifespan.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of data integrity.

Anaesthesia·2012
Same author

AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression.

Oncogene·2012
Same author

The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus.

Genes and immunity·2011
Same author

Cadmium, copper, iron, and zinc concentrations in kidneys of grey wolves, Canis lupus, from Alaska, Idaho, Montana (USA) and the Northwest Territories (Canada).

Bulletin of environmental contamination and toxicology·2010
Same author

Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007
Same author

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2007

Area of Science:

  • Gerontology
  • Mitochondrial Biology
  • Cellular Aging

Background:

  • Mitochondria are central to aging research, linked to the free radical theory of aging and oxidative stress.
  • Oxidative damage from mitochondrial electron transport chain (ETC) is implicated in senescence.
  • Mitochondrial DNA (mtDNA) mutations accumulate with age, potentially causing dysfunction.

Purpose of the Study:

  • To explore the multifaceted role of mitochondria in the aging process.
  • To investigate the mechanisms of mitochondrial oxidant generation and mtDNA damage.
  • To understand how mitochondrial regulation and turnover influence aging and age-related diseases.

Main Methods:

  • Review of existing literature on mitochondria and aging.
  • Analysis of studies on mitochondrial function decline with age.
  • Examination of research on mtDNA deletions and mutations in aging mammals.

Main Results:

  • Mitochondrial oxidants significantly contribute to cellular oxidative stress.
  • mtDNA deletions and mutations increase with age in various species.
  • Mitochondrial dysfunction is linked to aging, apoptosis, and lipofuscinogenesis.

Conclusions:

  • Mitochondria are critical in aging, with their dysfunction driving senescence.
  • Understanding mitochondrial oxidant generation and mtDNA damage is key to addressing aging.
  • Modulating mitochondrial function offers potential therapeutic strategies for age-related decline.

Related Experiment Videos