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Related Experiment Videos

Oxidative damage in the senescence-accelerated mouse

A Mori1, K Utsumi, J Liu

  • 1Okayama University Medical School, Japan.

Annals of the New York Academy of Sciences
|February 3, 1999
PubMed
Summary

Mitochondrial dysfunction contributes to accelerated aging in senescence-accelerated mice (SAMPS), shortening their lifespan. Longevity in white-footed mice (WF) remains unexplained by current mitochondrial findings.

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Area of Science:

  • Gerontology
  • Mitochondrial Biology
  • Comparative Biology

Background:

  • Senescence-accelerated mice (SAMPS) display premature aging and reduced lifespan, linked to oxidative stress.
  • Mitochondrial dysfunction is implicated in aging processes.
  • White-footed mice (WF) exhibit exceptional longevity, contrasting with SAMPS.

Purpose of the Study:

  • To investigate mitochondrial function in senescence-accelerated mice (SAMPS) and compare it with senescence-resistant (SAMR1) and long-lived white-footed (WF) mice.
  • To identify mitochondrial mechanisms contributing to accelerated aging in SAMPS.
  • To explore potential reasons for the extended lifespan in WF mice.

Main Methods:

  • Assessment of oxidative phosphorylation, respiratory control ratio, and ATP synthesis in liver mitochondria from SAMPS and SAMR1 mice.

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  • Evaluation of DNP-dependent uncoupled respiration and mitochondrial calcium uptake in SAMPS.
  • Mitochondrial function analysis in WF mice at different ages.

    • Main Results:

    • SAMPS mice showed decreased respiratory control ratio and ATP/O index with aging.
    • Mitochondrial respiration and calcium uptake were impaired in aging SAMPS mice.
    • No specific mitochondrial functional alterations were identified in young (3 and 12 months) WF mice that explain their longevity.

    Conclusions:

    • Mitochondrial functional disorders are strongly associated with the shortened lifespan of SAMPS.
    • Further investigation of aged WF mice is necessary to elucidate the mechanisms behind their remarkable longevity.