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Heterogeneity of clonal development in chronic myeloproliferative disorders
A M Ferraris1, R Mangerini, O Racchi
1Dipartimento di Oncologia Clinica e Sperimentale, Universitá di Genova and Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Abstract:
Recent reports have suggested a previously unexpected variability in the expression of the dominant neoplastic clone in myeloproliferative disorders (MPD). We evaluated 49 female patients with MPD and informative at the X-linked androgen receptor (AR) locus to establish the X chromosome inactivation pattern of hemopoietic cells. Whereas in chronic myelogenous leukemia (CML) the granulocytes (PMN) were uniformly of monoclonal origin, a striking heterogeneity of clonal development was found in PMN from patients with other MPD, with up to 50% of them expressing a polyclonal pattern of X inactivation.