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"Virtual" clinical trials: case control experiments utilizing a health services research workstation
1Division of General Internal Medicine, University of Pennsylvania School of Medicine, USA.
Proceedings. AMIA Symposium
|February 3, 1999
Summary
This study introduces a Health Services Research Workstation, enabling hypothesis testing on clinical and administrative data. It facilitates "virtual" clinical trials for disease association research.
Area of Science:
- Health Services Research
- Clinical Informatics
- Epidemiology
Background:
- Clinical and administrative data repositories are valuable for research.
- Designing and executing case-control studies requires efficient data access and hypothesis-testing tools.
Purpose of the Study:
- To develop an interface for a clinical and administrative data repository.
- To facilitate the design and execution of case-control experiments.
- To enable hypothesis generation and testing regarding disease and outcome associations.
Main Methods:
- Created an interface to a growing repository of clinical and administrative information.
- Developed an intuitive system for users to specify criteria for case selection and risk definition.
- Utilized comprehensive administrative and selected clinical data from 1994 onwards for ambulatory, emergency, and inpatient visits.
Main Results:
- Tested the system's ability to identify relationships between outpatient diagnoses (hypertension, osteoarthritis, hypercholesterolemia) and admissions for stroke and myocardial infarction.
- Achieved results consistent with previously published studies.
- Demonstrated the system's utility in validating findings from formal clinical trials on a local population.
Conclusions:
- The Health Services Research Workstation allows for "virtual" clinical trials.
- It can validate findings from formal clinical trials within a local population.
- Provides meaningful data analyses when formal clinical trials are not feasible.
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