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Related Experiment Videos

ErbB-3 and ErbB-4 expression in the mouse olfactory system

I Perroteau1, M Oberto, A Ieraci

  • 1Dipartimento di Biologia Animale e dell'Uomo, Università degli Studi di Torino, Italy. perroteau@dm.unito.it

Annals of the New York Academy of Sciences
|February 4, 1999
PubMed
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Neuregulins and ErbB receptors are crucial for olfactory system plasticity. ErbB-3 supports olfactory nerve cells, while ErbB-4 impacts olfactory bulb neurons, especially after injury.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neuregulins and ErbB receptors are vital for nervous system development and adult olfactory system plasticity.
  • The olfactory system retains significant neurogenesis and plasticity throughout adulthood.

Purpose of the Study:

  • To investigate the immunohistochemical localization of ErbB-3 and ErbB-4 in the adult mouse olfactory system.
  • To examine the expression changes of ErbB-3 and ErbB-4 following olfactory epithelium lesions.

Main Methods:

  • Immunohistochemistry was used to detect ErbB-3 and ErbB-4 expression in normal and lesioned adult mouse olfactory systems.
  • Olfactory epithelium lesions were induced using unilateral intranasal irrigation with ZnSO4.
  • Expression of olfactory marker protein (OMP) and tyrosine hydroxylase (TH) were also analyzed post-lesion.

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Main Results:

  • ErbB-3 expression was localized to olfactory nerve ensheathing cells and olfactory epithelium sustentacular cells.
  • ErbB-4 was found in olfactory bulb periglomerular and mitral/tufted cells, and in olfactory neurons and basal cells.
  • Lesions led to reduced ErbB-3 and ErbB-4 expression in the deafferented olfactory bulb, with TH expression decreasing in dopaminergic interneurons.

Conclusions:

  • Neuregulins likely mediate olfactory nerve ensheathing cell survival via ErbB-3 activation.
  • ErbB-4 activation appears critical for the functional activity of postsynaptic olfactory bulb neurons.
  • These findings highlight the role of the neuregulin-ErbB pathway in olfactory system maintenance and response to injury.