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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Articles linked to this work by shared authors, journal, and citation graph.

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[A comparative study of sphingolipids in transplanted melanomas with high and low metastatic activity].

Bioorganicheskaia khimiia·2008
Same author

[Bioeffector sphingolipids as stimulators of cell growth and survival].

Bioorganicheskaia khimiia·2004
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[The changes in the sphingenine/sphinganine ratio in sphingolipids of transplantable rat tumors depends on a transplantation organ].

Bioorganicheskaia khimiia·2003
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[Biologically effective sphingolipids devoid of 4-trans-double bond in the sphingoid hydrocarbon chain].

Bioorganicheskaia khimiia·2002
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[The relationship between the biological functions of sphingolipids and their chemical structure].

Bioorganicheskaia khimiia·2000
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[Changes in the activity of neutral and acidic isoforms of sphingomyelinase in hepatoma-22, regenerating and ischemic liver].

Voprosy meditsinskoi khimii·2000

Related Experiment Video

Updated: Jul 19, 2026

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

[Sphingolipids and cancer]

E V Diatlovitskaia1

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Bioorganicheskaia Khimiia
|February 4, 1999
PubMed
Summary

Tumor growth alters sphingolipids, impacting cell functions and immunity. Dietary sphingolipids and "sphingolipid" therapy offer potential in cancer treatment.

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Context:

  • Tumorigenesis involves significant alterations in cellular lipid metabolism.
  • Sphingolipids play crucial roles in cell signaling, proliferation, and immune responses.
  • Understanding these changes is vital for developing novel cancer therapies.

Purpose:

  • To review the qualitative and quantitative changes in sphingolipids during tumor growth.
  • To discuss the impact of these sphingolipid alterations on cell function and immunity.
  • To explore the role of dietary sphingolipids and sphingolipid-based therapies in cancer.

Summary:

  • Tumor progression is associated with distinct changes in sphingolipid profiles, including ceramides, sphingomyelins, and glycosphingolipids.
  • These sphingolipid modifications influence critical cellular processes and the tumor microenvironment's immunogenicity.

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Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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  • Dietary intake and therapeutic manipulation of sphingolipids are emerging strategies in oncology.

    • Impact:

    • Highlights the complex interplay between sphingolipids and cancer development.
    • Provides insights into potential therapeutic targets for cancer intervention.
    • Emphasizes the significance of sphingolipid metabolism in cancer biology and treatment strategies.