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Related Experiment Videos

[The HELLP syndrome]

D Váchová1, Z Hájek

  • 1I. gynekologicko-porodnická klinika 1. LF UK a VFN, Praha.

Casopis Lekaru Ceskych
|February 4, 1999
PubMed
Summary
This summary is machine-generated.

HELLP syndrome, a severe pregnancy complication often linked to preeclampsia, requires prompt diagnosis through specific lab findings: hemolysis, elevated liver enzymes, and low platelets. Early intervention is key to preventing serious maternal health issues.

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Critical Care Medicine

Context:

  • HELLP syndrome is a serious obstetric complication, frequently associated with severe preeclampsia.
  • It occurs in 2-12% of preeclampsia cases.
  • Diagnosis relies on specific laboratory markers: hemolysis (H), elevated liver enzymes (EL), and low platelets (LP).

Purpose:

  • To outline the diagnostic criteria for HELLP syndrome.
  • To describe the clinical presentation and symptoms.
  • To emphasize the importance of early diagnosis and treatment for preventing severe complications.

Summary:

  • Hemolysis is characterized by abnormal peripheral blood smear, elevated bilirubin (>1.2 mg/dl), and elevated lactate dehydrogenase (>40 mU/L).
  • Elevated liver enzymes include AST (>4.2 mU/L).

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  • A low platelet count (thrombocytes <100,000/mm³) is typical. Symptoms range from epigastric pain, nausea, and vomiting to non-specific flu-like symptoms.

    • Impact:

    • Accurate differential diagnosis and timely assessment are crucial for initiating treatment.
    • Prompt management can prevent severe complications like disseminated intravascular coagulopathy and hepatorenal failure.
    • Treatment is symptomatic, aiming to stabilize maternal condition, improve hemodynamics, and correct coagulation issues. Early pregnancy termination is a critical therapeutic step, depending on maternal and fetal status.