[Over a half century at the 1st Medical School of Charles University: development of interdisciplinary cooperation]

A vast interdisciplinary and methodological cooperation became a leading feature of pathology. It brought critical evaluation and synthesis of data from several points of view without prevalence of a pure structural empirism. Nevertheless, detailed structural analysis remains an unmatched and effective introductory way of diagnostic algorithms. A wide methodology is not always useful in its capacity but should be open to each of teachers. For the time being we rely more on outstanding personalities. Call for them as well as their reasonable uniting may restore the original sense to the School Scientific Council.