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[Autoimmune thyroid pathology in recently diagnosed diabetes mellitus type 1]
A Molina Lacasa1, M Fernández Castañer, M Pérez Maraver
1Servicio de Endocrinología, Ciutat Sanitària de Bellvitge, L'Hospitalet, Barcelona.
Revista Clinica Espanola
|February 4, 1999
Summary
Autoimmune thyroid disease is common in adults with new-onset type 1 diabetes (T1D). Patients with thyroid autoimmunity show higher beta-cell autoantibodies and a more severe T1D presentation.
Area of Science:
- Endocrinology
- Immunology
- Metabolic Disorders
Context:
- Type 1 diabetes (T1D) is an autoimmune disease characterized by beta-cell destruction.
- Autoimmune thyroid disease (AITD) is a common endocrine autoimmune disorder.
- Co-occurrence of T1D and AITD suggests shared autoimmune mechanisms.
Purpose:
- To determine the prevalence of AITD in adult patients with newly diagnosed T1D.
- To investigate the correlation between AITD and beta-cell autoimmunity markers (ICA, GAD, IA2).
- To examine the association between AITD and the clinical presentation of T1D.
Summary:
- A study of 100 adult patients with recent T1D diagnosis found a high prevalence of AITD (25%).
- Patients with positive anti-thyroid antibodies (Ac+) were predominantly female, had lower bicarbonate levels, and required more insulin.
- AITD patients exhibited higher titres of beta-cell autoantibodies (ICA, IA2) and a more severe clinical T1D presentation.
Impact:
- Highlights the significant co-occurrence of AITD in T1D patients.
- Suggests that thyroid autoimmunity may influence T1D severity and presentation.
- Underscores the need for screening T1D patients for thyroid dysfunction and vice versa.
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